Figure 1.

A scatter plot of the target structure probabilities on samples versus number of mutations from the seed. The ‘non-uniform’ sequences (black and white circles) are generated from the low-energy ensemble, whereas the ‘uniform’ sequences (triangles and crosses) are generated uniformly at random from all k-mutants consistent with the structures. The sequences satisfying the MFE criterion are indicated with a black circle (non-uniform) and a triangle (uniform). In both cases, we sampled 100 k-mutants for each k.