Table 1.
MicroRNAs inversely altered in HCC tissues and TPA-treated HepG2 cells
| microRNA name | Chromosomal location | Tissue miRNA levelsa |
Fold-change (T versus N) | Paired t-test P-value | HepG2 miRNA levelsa |
Fold change (TPA/DMSO) | Predicted targets | ||
|---|---|---|---|---|---|---|---|---|---|
| Normal | Tumor | DMSO | TPA | ||||||
| miR-139-5p | 11q13.4 | 12.73 ± 0.47 | 10.32 ± 1.27 | −5.35 | 1.54 × 10−7 | 6.72 | 9.25 | 5.79 | 617 |
| miR-199a-3p | 1q24.3, 19p13.2 | 10.83 ± 1.22 | 7.63 ± 2.29 | −9.16 | 9.02 × 10−6 | 4.65 | 7.02 | 5.17 | 531 |
| miR-101 | 1p31.3, 9p24.1 | 6.07 ± 0.84 | 4.98 ± 0.90 | −2.13 | 1.48 × 10−5 | 5.54 | 7.28 | 3.35 | 1004 |
| miR-10b | 2q31.1 | 5.21 ± 0.73 | 7.20 ± 1.53 | 3.98 | 5.57 × 10−5 | 11.10 | 9.13 | −3.92 | 329 |
| miR-100 | 11q24.1 | 12.47 ± 0.83 | 10.39 ± 2.90 | −4.22 | 5.94 × 10−3 | 3.90 | 7.74 | 14.36 | 39 |
| miR-22 | 17p13.3 | 12.45 ± 1.53 | 11.41 ± 1.92 | −2.06 | 7.08 × 10−3 | 6.50 | 8.09 | 3.00 | 459 |
amiRNA levels expressed as 39-Ct, Tissue miRNA levels expressed as mean ± SD.