Table 2.

Functional classification of differentially expressed genes in HCC

Cluster name	No. of genes	No. of enriched GO termsa	Enrichment P-valuesb	Biological function
C1	98	37 (109)	1.29 × 10−4	GO:0015031∼protein transport
				GO:0045184∼establishment of protein localization
				GO:0055085∼transmembrane transport
				GO:0046907∼intracellular transport
				GO:0016192∼vesicle-mediated transport
C2	166	36 (127)	1.45 × 10−2	GO:0002526∼acute inflammatory response
				GO:0042158∼lipoprotein biosynthetic process
				GO:0006954∼inflammatory response
				GO:0042157∼lipoprotein metabolic process
				GO:0007596∼blood coagulation
C3	81	97 (138)	2.63 × 10−9	GO:0000087∼M phase of mitotic cell cycle
				GO:0000280∼nuclear division
				GO:0007067∼mitosis
				GO:0051726∼regulation of cell cycle
				GO:0000075∼cell cycle checkpoint
C4	242	284 (459)	1.07 × 10−3	GO:0007165∼signal transduction
				GO:0007242∼intracellular signaling cascade
				GO:0007243∼protein kinase cascade
				GO:0006915∼apoptosis
				GO:0042981∼regulation of apoptosis
C5	208	84 (135)	5.89 × 10−4	GO:0006412∼translation
				GO:0006397∼mRNA processing
				GO:0008380∼RNA splicing
				GO:0019752∼carboxylic acid metabolic process
				GO:0010608∼posttranscriptional regulation of gene expression
C6	306	68 (119)	2.04 × 10−12	GO:0045449∼regulation of transcription
				GO:0010468∼regulation of gene expression
				GO:0031323∼regulation of cellular metabolic process
				GO:0006325∼chromatin organization
				GO:0016568∼chromatin modification

^aTerms with enrichment P-value < 0.05; total number of GO terms are shown in parenthesis.

^bEnrichment P-value calculated using DAVID.