Table 2.
Cluster name | No. of genes | No. of enriched GO termsa | Enrichment P-valuesb | Biological function |
---|---|---|---|---|
C1 | 98 | 37 (109) | 1.29 × 10−4 | GO:0015031∼protein transport |
GO:0045184∼establishment of protein localization | ||||
GO:0055085∼transmembrane transport | ||||
GO:0046907∼intracellular transport | ||||
GO:0016192∼vesicle-mediated transport | ||||
C2 | 166 | 36 (127) | 1.45 × 10−2 | GO:0002526∼acute inflammatory response |
GO:0042158∼lipoprotein biosynthetic process | ||||
GO:0006954∼inflammatory response | ||||
GO:0042157∼lipoprotein metabolic process | ||||
GO:0007596∼blood coagulation | ||||
C3 | 81 | 97 (138) | 2.63 × 10−9 | GO:0000087∼M phase of mitotic cell cycle |
GO:0000280∼nuclear division | ||||
GO:0007067∼mitosis | ||||
GO:0051726∼regulation of cell cycle | ||||
GO:0000075∼cell cycle checkpoint | ||||
C4 | 242 | 284 (459) | 1.07 × 10−3 | GO:0007165∼signal transduction |
GO:0007242∼intracellular signaling cascade | ||||
GO:0007243∼protein kinase cascade | ||||
GO:0006915∼apoptosis | ||||
GO:0042981∼regulation of apoptosis | ||||
C5 | 208 | 84 (135) | 5.89 × 10−4 | GO:0006412∼translation |
GO:0006397∼mRNA processing | ||||
GO:0008380∼RNA splicing | ||||
GO:0019752∼carboxylic acid metabolic process | ||||
GO:0010608∼posttranscriptional regulation of gene expression | ||||
C6 | 306 | 68 (119) | 2.04 × 10−12 | GO:0045449∼regulation of transcription |
GO:0010468∼regulation of gene expression | ||||
GO:0031323∼regulation of cellular metabolic process | ||||
GO:0006325∼chromatin organization | ||||
GO:0016568∼chromatin modification |
aTerms with enrichment P-value < 0.05; total number of GO terms are shown in parenthesis.
bEnrichment P-value calculated using DAVID.