. 2012 Aug 24;40(20):10478–10493. doi: 10.1093/nar/gks789

Table 4.

Topological properties of the top 5% objects in cluster C6 network

GeneGO object name	Mappedgene symbol	Molecular function	DEGs	Predicted targets^a	miRNA subnetwork^b	Betweenness		No. of interactions (degree)
						Value	Rank* (%)	Total	In	Out	Rank^c (%)
AP-1	FOS	TF		101, 139-5p, 199-3p	101, 139-5p, 199a-3p	249208.61	0.14	291	112	179	0.14
EGR1	EGR1	TF	Yes		101, 139-5p, 199a-3p	72295.33	0.27	125	32	93	0.28
miR-101	miR-101					56924.00	0.41	77	4	73	0.42
HNF4-alpha	HNF4A	TF			101, 139-5p	44757.16	0.54	69	8	61	0.56
miR-139-5p	miR-139-5p					30350.00	0.68	50	1	49	0.99
c-Myc	MYC	TF			101, 139-5p, 199a-3p	26864.92	0.82	63	25	38	1.41
SP1/SP3 complex	SP1	TF		199-3p	101, 139-5p, 199a-3p	26196.43	0.95	70	14	56	0.70
NF-Y	NFYA				199a-3p	25680.85	1.09	63	12	51	0.85
Tcf(Lef)	LEF1	TF			101, 139-5p, 199a-3p	22192.08	1.22	59	24	35	1.55
ESR1 (nuclear)	ESR1	TF			101, 139-5p, 199a-3p	21792.08	1.36	54	22	32	1.83
p53	TP53	TF			101, 139-5p, 199a-3p	21048.43	1.50	57	28	29	2.11
IGF-1	IGF-1				101, 139-5p, 199a-3p	20782.87	1.63	46	36	10	7.46
KLF4	KLF4	TF	Yes		101, 139-5p	20556.33	1.77	55	25	30	1.97
C/EBPdelta	CEBPD	TF	Yes		101, 139-5p, 199a-3p	19309.54	1.90	61	36	25	2.54
miR-199a-3p	miR-199a-3p				101	18887.15	2.04	55	13	42	1.13
NF-kB	RELA	TF			101, 139-5p	17556.05	2.18	41	15	26	2.39
ERK1/2	ERK1/2					16240.25	2.31	27	13	14	4.93
EZH2	EZH2	EPIGENES	Yes	101	101, 139-5p, 199a-3p	15792.27	2.45	53	13	40	1.27
Androgen receptor	AR	TF			101, 139-5p	13974.19	2.59	40	20	20	3.24
JAK2	JAK2			101	101, 139-5p	13876.60	2.72	26	11	15	4.65
c-Src	SRC				101, 139-5p	13570.23	2.86	22	13	9	9.01
MEKK1(MAP3K1)	MAP3K1					12517.24	2.99	10	7	3	24.08
N-CoR	NCOR1	TF	Yes		101, 139-5p	12444.68	3.13	47	14	33	1.69
STAT3	STAT3	TF			101, 139-5p	12201.45	3.27	28	12	16	4.08
p16INK4	CDKN2A		Yes		101, 139-5p, 199a-3p	11640.78	3.40	45	41	4	18.17
mTOR	MTOR		Yes		101, 139-5p	9691.05	3.54	30	20	10	7.46
SUZ12	SUZ12	EPIGENES	Yes		199a-3p	9046.93	3.67	40	12	28	2.25
Caspase-3	CASP3			101, 139-5p	101, 139-5p	8983.41	3.81	12	3	9	9.01
IRF8	IRF8	TF	Yes			8469.37	3.95	35	12	23	2.82
Ubiquitin	UBB				101, 139-5p, 199a-3p	8159.22	4.08	31	9	22	2.96
LRH1	NR5A2	TF	Yes	139-5p	101, 139-5p	7736.99	4.22	38	27	11	6.34
ATF-3	ATF3	TF	Yes		101, 139-5p, 199a-3p	7376.23	4.35	39	22	17	3.94
Cathepsin L	Cathepsin L				101, 139-5p, 199a-3p	7358.72	4.49	26	22	4	18.17
ZNF143	ZNF143	TF	Yes	101	101	7337.00	4.63	15	5	10	7.46

^aPredicted by TargetScan and context score <−0.2.

^bThe components in specific miRNA-subnetworks.

^cRank percentile.