Table 4.
GeneGO object name | Mappedgene symbol | Molecular function | DEGs | Predicted targetsa | miRNA subnetworkb | Betweenness |
No. of interactions (degree) |
||||
---|---|---|---|---|---|---|---|---|---|---|---|
Value | Rank* (%) | Total | In | Out | Rankc (%) | ||||||
AP-1 | FOS | TF | 101, 139-5p, 199-3p | 101, 139-5p, 199a-3p | 249208.61 | 0.14 | 291 | 112 | 179 | 0.14 | |
EGR1 | EGR1 | TF | Yes | 101, 139-5p, 199a-3p | 72295.33 | 0.27 | 125 | 32 | 93 | 0.28 | |
miR-101 | miR-101 | 56924.00 | 0.41 | 77 | 4 | 73 | 0.42 | ||||
HNF4-alpha | HNF4A | TF | 101, 139-5p | 44757.16 | 0.54 | 69 | 8 | 61 | 0.56 | ||
miR-139-5p | miR-139-5p | 30350.00 | 0.68 | 50 | 1 | 49 | 0.99 | ||||
c-Myc | MYC | TF | 101, 139-5p, 199a-3p | 26864.92 | 0.82 | 63 | 25 | 38 | 1.41 | ||
SP1/SP3 complex | SP1 | TF | 199-3p | 101, 139-5p, 199a-3p | 26196.43 | 0.95 | 70 | 14 | 56 | 0.70 | |
NF-Y | NFYA | 199a-3p | 25680.85 | 1.09 | 63 | 12 | 51 | 0.85 | |||
Tcf(Lef) | LEF1 | TF | 101, 139-5p, 199a-3p | 22192.08 | 1.22 | 59 | 24 | 35 | 1.55 | ||
ESR1 (nuclear) | ESR1 | TF | 101, 139-5p, 199a-3p | 21792.08 | 1.36 | 54 | 22 | 32 | 1.83 | ||
p53 | TP53 | TF | 101, 139-5p, 199a-3p | 21048.43 | 1.50 | 57 | 28 | 29 | 2.11 | ||
IGF-1 | IGF-1 | 101, 139-5p, 199a-3p | 20782.87 | 1.63 | 46 | 36 | 10 | 7.46 | |||
KLF4 | KLF4 | TF | Yes | 101, 139-5p | 20556.33 | 1.77 | 55 | 25 | 30 | 1.97 | |
C/EBPdelta | CEBPD | TF | Yes | 101, 139-5p, 199a-3p | 19309.54 | 1.90 | 61 | 36 | 25 | 2.54 | |
miR-199a-3p | miR-199a-3p | 101 | 18887.15 | 2.04 | 55 | 13 | 42 | 1.13 | |||
NF-kB | RELA | TF | 101, 139-5p | 17556.05 | 2.18 | 41 | 15 | 26 | 2.39 | ||
ERK1/2 | ERK1/2 | 16240.25 | 2.31 | 27 | 13 | 14 | 4.93 | ||||
EZH2 | EZH2 | EPIGENES | Yes | 101 | 101, 139-5p, 199a-3p | 15792.27 | 2.45 | 53 | 13 | 40 | 1.27 |
Androgen receptor | AR | TF | 101, 139-5p | 13974.19 | 2.59 | 40 | 20 | 20 | 3.24 | ||
JAK2 | JAK2 | 101 | 101, 139-5p | 13876.60 | 2.72 | 26 | 11 | 15 | 4.65 | ||
c-Src | SRC | 101, 139-5p | 13570.23 | 2.86 | 22 | 13 | 9 | 9.01 | |||
MEKK1(MAP3K1) | MAP3K1 | 12517.24 | 2.99 | 10 | 7 | 3 | 24.08 | ||||
N-CoR | NCOR1 | TF | Yes | 101, 139-5p | 12444.68 | 3.13 | 47 | 14 | 33 | 1.69 | |
STAT3 | STAT3 | TF | 101, 139-5p | 12201.45 | 3.27 | 28 | 12 | 16 | 4.08 | ||
p16INK4 | CDKN2A | Yes | 101, 139-5p, 199a-3p | 11640.78 | 3.40 | 45 | 41 | 4 | 18.17 | ||
mTOR | MTOR | Yes | 101, 139-5p | 9691.05 | 3.54 | 30 | 20 | 10 | 7.46 | ||
SUZ12 | SUZ12 | EPIGENES | Yes | 199a-3p | 9046.93 | 3.67 | 40 | 12 | 28 | 2.25 | |
Caspase-3 | CASP3 | 101, 139-5p | 101, 139-5p | 8983.41 | 3.81 | 12 | 3 | 9 | 9.01 | ||
IRF8 | IRF8 | TF | Yes | 8469.37 | 3.95 | 35 | 12 | 23 | 2.82 | ||
Ubiquitin | UBB | 101, 139-5p, 199a-3p | 8159.22 | 4.08 | 31 | 9 | 22 | 2.96 | |||
LRH1 | NR5A2 | TF | Yes | 139-5p | 101, 139-5p | 7736.99 | 4.22 | 38 | 27 | 11 | 6.34 |
ATF-3 | ATF3 | TF | Yes | 101, 139-5p, 199a-3p | 7376.23 | 4.35 | 39 | 22 | 17 | 3.94 | |
Cathepsin L | Cathepsin L | 101, 139-5p, 199a-3p | 7358.72 | 4.49 | 26 | 22 | 4 | 18.17 | |||
ZNF143 | ZNF143 | TF | Yes | 101 | 101 | 7337.00 | 4.63 | 15 | 5 | 10 | 7.46 |
aPredicted by TargetScan and context score <−0.2.
bThe components in specific miRNA-subnetworks.
cRank percentile.