Table 10.
Effect of Nuna kadugu on organ weight of experimental Sprague Dawley rats in repeated oral toxicity study
| Treatment | Sex |
Organ Weight (gms) |
|||||
|---|---|---|---|---|---|---|---|
| Kidneys | Adrenals | Thymus | Testis/Ovaries | Epididymis | |||
|
Control (0.5% CMC) |
M(n=5) |
1.65±0.13 |
0.05±0.01 |
0.48±0.01 |
2.06±0.42 |
1.43±0.03 |
|
| F (n=5) |
1.34±0.13 |
0.04±0.00 |
0.48±0.03 |
0.08±0.02 |
- |
||
| MF(n=10) |
1.49±0.10 |
0.04± 0.00 |
0.48±0.01 |
- |
- |
||
|
NK |
(300 mg/kg p.o/day) |
M(n=5) |
1.79±0.12 |
0.05±0.01 |
0.48±0.01 |
2.09±0.17 |
1.41±0.03 |
| F (n=5) |
1.35±0.04 |
0.05±0.01 |
0.49±0.02 |
0.32±0.02 |
- |
||
| MF(n=10) |
1.57±0.09 |
0.05±0.00 |
0.48±0.01 |
- |
- |
||
|
(600 mg/kg p.o/day) |
M(n=5) |
1.61±0.10 |
0.04±0.00 |
0.47±0.02 |
1.96±0.19 |
1.47±0.03 |
|
| F (n=5) |
1.36±0.07 |
0.04±0.00 |
0.48±0.01 |
0.08±0.01 |
- |
||
| MF(n=10) |
1.49±0.07 |
0.04±0.00 |
0.47±0.01 |
- |
- |
||
|
(900mg/kg p.o/day) |
M(n=5) |
1.64±0.14 |
0.04±0.00 |
0.47±0.01 |
2.22±0.38 |
1.49±0.03 |
|
| F (n=5) |
1.37±0.08 |
0.05±0.01 |
0.52±0.03 |
0.09±0.01 |
- |
||
| MF(n=10) |
1.51±0.09 |
0.05±0.00 |
0.49±0.02 |
- |
- |
||
|
Satellite group | |||||||
|
Control (0.5% CMC) |
M(n=5) |
1.51±0.12 |
0.05±0.01 |
0.46±0.02 |
1.98±0.43 |
1.41±0.03 |
|
| F (n=5) |
1.34±0.07 |
0.05±0.00 |
0.49±0.02 |
0.10±0.01 |
- |
||
| MF(n=10) |
1.42±0.07 |
0.05±0.00 |
0.48±0.01 |
- |
- |
||
| NK (900 mg/kg p.o/day) | M(n=5) |
1.68±0.10 |
0.05±0.00 |
0.490.02 |
2.04±0.31 |
1.54±0.02 |
|
| F (n=5) |
1.35±0.05 |
0.05±0.00 |
0.51±0.03 |
0.12±0.00 |
|
||
| MF(n=10) | 1.51±0.08 | 0.05±0.00 | 0.50±0.02 | 1.98±0.43 | |||
Values expressed as mean ± SEM; n=10 (5/sex); Significance with Tukey’s test following one way ANOVA is evaluated as *p < 0.05 and **p < 0.01 vs control group.