Table 11.
Effect of Nuna kadugu on relative organ weight of experimental Sprague Dawley rats in repeated oral toxicity study
| Treatment | Sex |
Relative organ weight (g %) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Brain | Heart | Liver | Spleen | Kidney | Adrenal |
Sex organs |
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| Testis | Ovaries | |||||||||||||||||||
|
Control (0.5% CMC) |
M (n=5) |
0.99±0.06 |
0.38±0.02 |
3.53±0.22 |
0.47±0.03 |
0.88±0.03 |
0.03±0.00 |
1.07±0.15 |
- |
|||||||||||
| F (n=5) |
1.05±0.04 |
0.42±0.43 |
4.21±0.35 |
0.49±0.02 |
0.79±0.08 |
0.02±0.00 |
- |
0.05±0.01 |
||||||||||||
| MF (n=10) |
1.02±0.03 |
0.40±0.02 |
3.87±0.23 |
0.48±0.02 |
0.84±0.04 |
0.02±0.00 |
- |
- |
||||||||||||
|
NK |
(300 mg/kg p.o/day) |
M (n=5) |
0.97±0.08 |
0.41±0.01 |
3.70±0.14 |
0.54±0.11 |
0.93±0.06 |
0.02±0.00 |
1.12±0.15 |
- |
||||||||||
| F (n=5) |
1.10±0.05 |
0.40±0.02 |
3.79±0.28 |
0.42±0.04 |
0.85±0.03 |
0.03±0.00 |
- |
0.07±0.01 |
||||||||||||
| MF (n=10) |
1.04±0.05 |
0.40±0.01 |
3.74±0.15 |
0.48±0.06 |
0.89±0.03 |
0.03±0.00 |
- |
- |
||||||||||||
|
(600 mg/kg p.o/day) |
M (n=5) |
1.06±0.12 |
0.40±0.03 |
3.99±0.75 |
0.43±0.06 |
0.96±0.15 |
0.02±0.00 |
1.16±0.20 |
- |
|||||||||||
| F (n=5) |
1.00±0.04 |
0.39±0.03 |
3.45±0.12 |
0.38±0.03 |
0.77±0.03 |
0.02±0.00 |
- |
0.05±0.01 |
||||||||||||
| MF (n=10) |
1.03±0.06 |
0.40±0.02 |
3.72±0.37 |
0.40±0.03 |
0.86±0.08 |
0.02±0.00 |
- |
- |
||||||||||||
|
(900mg/kg p.o/day) |
M (n=5) |
0.97±0.06 |
0.38±0.02 |
3.63±0.41 |
0.48±0.04 |
0.84±0.03 |
0.02±0.00 |
1.11±0.16 |
- |
|||||||||||
| F (n=5) |
1.14±0.04 |
0.40±0.01 |
3.90±0.19 |
0.52±0.06 |
0.85±0.02 |
0.03±0.00 |
- |
0.06±0.01 |
||||||||||||
| MF (n=10) |
1.05±0.05 |
0.39±0.01 |
3.76±0.22 |
0.50±0.03 |
0.84±0.02 |
0.03±0.00 |
- |
- |
||||||||||||
|
Satellite group |
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|
Control (0.5% CMC) |
M (n=5) |
1.03±0.10 |
0.41±0.02 |
3.93±0.26 |
0.41±0.03 |
0.83±0.05 |
0.03±0.00 |
1.07±0.19 |
- |
|||||||||||
| F (n=5) |
1.08±0.04 |
0.36±0.01 |
3.91±0.25 |
0.46±0.05 |
0.84±0.04 |
0.03±0.00 |
- |
0.07±0.01 |
||||||||||||
| MF (n=10) |
1.05±0.05 |
0.39±0.01 |
3.92±0.17 |
0.44±0.03 |
0.83±0.03 |
0.03±0.00 |
- |
- |
||||||||||||
| NK (900 mg/kg p.o/day) | M (n=5) |
0.99±0.04 |
0.41±0.04 |
4.06±0.27 |
0.49±0.03 |
0.89±0.04 |
0.03±0.00 |
1.07±0.12 |
- |
|||||||||||
| F (n=5) |
1.02±0.03 |
0.39±0.04 |
3.41±0.44 |
0.39±0.04 |
0.77±0.07 |
0.03±0.00 |
- |
0.07±0.01 |
||||||||||||
| MF (n=10) | 1.02±0.02 | 0.40±0.03 | 3.74±0.27 | 0.44±0.03 | 0.83±0.04 | 0.03±0.00 | - | - | ||||||||||||
Values expressed as mean ± SEM; n=10 (5/sex); Significance with Tukey’s test following one way ANOVA is evaluated as *p < 0.05 and **p < 0.01 vs control group.