Table 8.
Effect of Nuna kadugu on biochemical parameters of experimental Sprague Dawley rats in repeated oral toxicity study
| Treatment | Sex |
Biochemical parameters |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Glucose (mg/dl) | Cholesterol (mg/dl) | Triglycerides (mg/dl) | T. Protein (gm%) | Albumin (gm%) | SGOT (IU/l) | SGPT (IU/l) | |||
|
Control (0.5% CMC) |
M(n=5) |
128.90 ±12.51 |
88.01 ±5.69 |
45.18 ±8.56 |
4.63 ±0.28 |
2.27 ±0.13 |
30.40 ±4.04 |
33.92 ±3.38 |
|
| F (n=5) |
134.24 ±5.13 |
86.64 ±7.32 |
50.50 ±9.00 |
4.70 ±0.34 |
2.38 ±0.23 |
29.40 ±4.12 |
43.16 ±7.41 |
||
| MF(n=10) |
131.57±6.44 |
87.32±4.38 |
47.84±5.92 |
4.67±0.21 |
2.33±0.13 |
29.90±2.73 |
38.54±4.14 |
||
|
NK |
(300 mg/kg p.o/day) |
M(n=5) |
131.16 ±9.57 |
87.98 ±10.81 |
51.20 ±11.66 |
4.90 ±0.13 |
2.43 ±0.15 |
29.92 ±5.31 |
43.83 ±6.02 |
| F (n=5) |
130.31 ±11.64 |
87.74 ±13.2 |
44.79 ±3.18 |
5.01 ±0.15 |
2.34 ±0.23 |
29.90 ±3.93 |
34.19 ±4.42 |
||
| MF(n=10) |
130.74±7.11 |
87.86±8.05 |
47.99±5.80 |
4.96±0.09 |
2.39±0.13 |
29.91±3.11 |
39.01±3.87 |
||
|
(600 mg/kg p.o/day) |
M(n=5) |
128.35 ±12.39 |
89.26 ±3.32 |
50.57 ±1.53 |
4.82 ±0.27 |
2.22 ±0.29 |
29.10 ±3.69 |
40.99 ±4.52 |
|
| F (n=5) |
132.61 ±15.43 |
85.92 ±10.74 |
44.74 ±3.50 |
4.78 ±0.49 |
2.20 ±0.23 |
31.22 ±4.86 |
38.66 ±3.67 |
||
| MF(n=10) |
130.48±9.35 |
87.59±5.33 |
47.66±2.05 |
4.80±0.26 |
2.21±0.18 |
30.16±2.90 |
39.83±2.77 |
||
|
(900mg/kg p.o/day) |
M(n=5) |
130.18 ±2.79 |
85.73 ±14.31 |
47.91 ±6.91 |
4.95 ±0.50 |
2.33 ±0.30 |
30.20 ±4.21 |
38.56 ±6.79 |
|
| F (n=5) |
130.58 ±13.84 |
88.77 ±14.81 |
47.05 ±5.99 |
4.66 ±0.28 |
2.24 ±0.13 |
31.08 ±6.96 |
41.00 ±8.08 |
||
| MF(n=10) |
130.38±6.66 |
87.25±9.72 |
47.48±4.31 |
4.80±0.28 |
2.28±0.15 |
30.64±3.84 |
39.78±4.99 |
||
|
Satellite group | |||||||||
|
Control (0.5% CMC) |
M(n=5) |
134.32 ±8.85 |
89.59 ±10.96 |
47.55 ±3.73 |
4.92 ±0.32 |
2.34 ±0.25 |
31.14 ±1.17 |
39.68 ±4.37 |
|
| F (n=5) |
127.92 ±12.83 |
85.61 ±10.53 |
48.65 ±2.67 |
5.05 ±0.45 |
2.12 ±0.22 |
29.54 ±4.74 |
39.01 ±2.98 |
||
| MF(n=10) |
131.12±7.42 |
87.60±7.19 |
48.10±2.17 |
4.99±0.26 |
2.23±0.16 |
30.34±2.32 |
39.35±2.50 |
||
|
NK (900 mg/kg p.o/day) |
M(n=5) |
131.55 ±4.12 |
87.57 ±5.61 |
46.79 ±5.22 |
4.80 ±0.31 |
2.20 ±0.13 |
24.96 ±4.73 |
39.88 ±4.38 |
|
| F (n=5) |
132.35 ±14.32 |
86.61 ±13.93 |
49.42 ±4.24 |
4.71 ±0.33 |
2.42 ±0.19 |
35.36 ±3.85 |
38.66 ±7.83 |
||
| MF(n=10) |
131.95±7.02 |
87.09±7.08 |
48.11±3.20 |
4.75±0.21 |
2.31±0.12 |
30.16±3.36 |
39.27±4.24 |
||
|
Treatment |
Sex |
Biochemical parameters |
|||||||
|
LDH (IU/L) |
ALP (IU/L) |
γ-GT (IU/L) |
Bilirubin (mg/dl) |
Creatinine (mg%) |
BUN (mg/dl) |
||||
|
Control (0.5% CMC) |
M(n=5) |
178.20±9.72 |
329.00±46.89 |
2.39±0.23 |
0.83±0.03 |
0.43±0.05 |
19.07±0.63 |
||
| F (n=5) |
180.60±12.33 |
286.80±51.41 |
2.11±0.14 |
0.90±0.03 |
0.31±0.03 |
20.18±1.43 |
|||
| MF(n=10) |
179.40±7.41 |
307.90±33.55 |
2.25±0.13 |
0.87±0.02 |
0.37±0.03 |
19.63±0.76 |
|||
|
NK |
(300 mg/kg .o/day) |
M(n=5) |
179.60±16.64 |
307.22±18.45 |
2.12±0.19 |
0.54±0.27 |
0.28±0.02 |
19.06±3.10 |
|
| F (n=5) |
178.20±12.08 |
310.06±14.29 |
2.10±0.20 |
1.00±0.08 |
0.35±0.03 |
18.08±1.28 |
|||
| MF(n=10) |
178.90±9.69 |
308.64±11.01 |
2.11±0.13 |
0.77±0.15 |
0.31±0.02 |
18.57±1.59 |
|||
|
(600 mg/kg p.o/day) |
M(n=5) |
181.40±7.28 |
306.74±16.29 |
2.03±0.23 |
0.84±0.05 |
0.34±0.04 |
18.56±2.11 |
||
| F (n=5) |
179.80±11.51 |
311.32±32.42 |
1.96±0.20 |
0.84±0.06 |
0.34±0.04 |
20.26±1.33 |
|||
| MF(n=10) |
180.60±6.42 |
309.03±25.89 |
1.99±0.14 |
0.84±0.04 |
0.34±0.03 |
19.41±1.21 |
|||
|
(900mg/kg p.o/day) |
M(n=5) |
178.20±14.03 |
310.82±35.07 |
2.04±0.21 |
0.99±0.04 |
0.37±0.03 |
19.62±1.65 |
||
| F (n=5) |
183.60±8.59 |
306.64±31.52 |
2.13±0.22 |
0.97±0.02 |
0.30±0.03 |
18.55±2.00 |
|||
| MF(n=10) |
180.90±7.81 |
308.73±35.56 |
2.09±0.14 |
0.98±0.02 |
0.33±0.02 |
19.09±1.24 |
|||
|
Satellite group | |||||||||
|
Control (0.5% CMC) |
M(n=5) |
180.60±10.13 |
288.66±20.91 |
2.01±0.25 |
0.92±0.06 |
0.32±0.03 |
19.88±0.86 |
||
| F (n=5) |
181.60±16.71 |
330.98±50.39 |
2.06±0.28 |
0.93±0.05 |
0.34±0.03 |
20.78±1.10 |
|||
| MF(n=10) |
181.10±9.21 |
309.82±26.66 |
2.04±0.18 |
0.93±0.04 |
0.33±0.02 |
20.33±0.68 |
|||
| NK (900 mg/kg p.o/day) | M(n=5) |
180.20±13.43 |
310.80±33.66 |
2.28±0.29 |
0.96±0.13 |
0.38±0.04 |
21.21±2.33 |
||
| F (n=5) |
181.20±14.59 |
308.42±36.41 |
1.85±0.23 |
0.930.04± |
0.31±0.03 |
20.48±1.60 |
|||
| MF(n=10) | 180.70±9.35 | 309.61±23.38 | 2.06±0.19 | 0.94±0.06 | 0.35±0.03 | 20.85±1.34 | |||
Values expressed as mean ± SEM; Significance with Tukey’s test following one way ANOVA is evaluated as *p < 0.05 and **p < 0.01 vs control group. SGOT – Serum Glutamate oxaloacetate transaminase; SGPT – Serum Glutamate pyruvate transaminase.
Values expressed as mean ± SEM; n=10 (5/sex); Significance with Tukey’s test following one way ANOVA is evaluated as *p < 0.05 and **p < 0.01 vs control group. LDH – Lactate dehydrogenase; ALP- Alkaline Phosphatase; GGT- Gamma Glutamyl Transferase; BUN – Blood Urea Nitrogen.