Table 9.
Effect of Nuna kadugu on serum electrolytes of experimental Sprague Dawley rats in repeated oral toxicity study
| Treatment | Sex |
Serum electrolytes (mmol/l) |
|||||
|---|---|---|---|---|---|---|---|
| Sodium | Potassium | Chloride | Total Calcium | pH | |||
|
Control (0.5% CMC) |
M(n=5) |
136.46±0.59 |
4.68±0.19 |
99.48±1.32 |
2.38±0.02 |
7.35±0.09 |
|
| F (n=5) |
140.09±0.86 |
4.06±0.10 |
100.94±1.95 |
2.45±0.02 |
7.42±0.13 |
||
| MF(n=10) |
138.28±0.78 |
4.37±0.14 |
100.21±1.14 |
2.42±0.02 |
7.39±0.08 |
||
|
NK |
(300 mg/kg p.o/day) |
M(n=5) |
139.03±0.73 |
4.40±0.15 |
99.49±1.14 |
2.33±0.08 |
7.41±0.09 |
| F (n=5) |
137.76±0.31 |
4.02±0.08 |
99.20±0.49 |
2.47±0.02 |
7.40±0.06 |
||
| MF(n=10) |
138.39±0.43 |
4.21±0.10 |
99.34±0.59 |
2.40±0.05 |
7.40±0.05 |
||
|
(600 mg/kg p.o/day) |
M(n=5) |
138.12±0.70 |
4.35±0.12 |
99.53±0.33 |
2.47±0.01 |
7.38±0.11 |
|
| F (n=5) |
138.03±1.04 |
4.08±0.12 |
100.27±0.53 |
2.38±0.03 |
7.39±0.05 |
||
| MF(n=10) |
138.07±0.59 |
4.21±0.09 |
99.90±0.32 |
2.42±0.02 |
7.39±0.06 |
||
|
(900mg/kg p.o/day) |
M(n=5) |
142.58±1.20 |
4.23±0.13 |
102.82±1.09 |
2.41±0.02 |
7.40±0.09 |
|
| F (n=5) |
134.75±2.47 |
4.19±0.12 |
98.15±1.03 |
2.41±0.05 |
7.36±0.10 |
||
| MF(n=10) |
138.67±1.84 |
4.21±0.08 |
100.49±1.05 |
2.41±0.03 |
7.38±0.06 |
||
|
Satellite group | |||||||
|
Control (0.5% CMC) |
M(n=5) |
147.40±1.68 |
4.25±0.04 |
100.43±1.62 |
2.36±0.07 |
7.39±0.09 |
|
| F (n=5) |
132.23±6.90 |
4.19±0.05 |
101.02±1.62 |
2.44±0.07 |
7.39±0.04 |
||
| MF(n=10) |
139.82±4.19 |
4.22±0.03 |
100.73±1.09 |
2.40±0.05 |
7.39±0.04 |
||
| NK (900 mg/kg p.o/day) | M(n=5) |
140.23±1.15 |
4.25±0.07 |
102.02±1.83 |
2.35±0.09 |
7.40±0.13 |
|
| F (n=5) |
139.57±0.98 |
4.20±0.08 |
99.79±3.32 |
2.42±0.07 |
7.40±0.15 |
||
| MF(n=10) | 139.90 ± 0.72 | 4.23± 0.05 | 100.90 ± 1.82 | 2.39± 0.05 | 7.40 ± 0.09 | ||
Values expressed as mean ± SEM; n=10 (5/sex); Significance with Tukey’s test following one way ANOVA is evaluated as *p < 0.05 and **p < 0.01 vs control group.