Table 2.
Results from univariate Cox regression analyses of clinicopathologic parameters including blood group status on overall survival
| Parameter | Category | N | Events | HR | 95% CI | P-value |
|---|---|---|---|---|---|---|
| Age |
<70 years |
426 |
273 |
1 |
|
<0.0001 |
| |
≥70 years |
194 |
139 |
1.54 |
1.26 – 1.89 |
|
| Sex |
Male |
336 |
235 |
1 |
|
0.21 |
| |
Female |
284 |
177 |
0.88 |
0.73 – 1.07 |
|
| Tumor size |
pT1/2 |
19 |
13 |
0.70 |
0.40 – 1.21 |
0.19 |
| |
pT3/4 |
601 |
399 |
1 |
|
|
| Lymph node status |
Negative |
111 |
68 |
1 |
|
0.0077 |
| |
Positive |
509 |
344 |
1.42 |
1.10 – 1.85 |
|
| Procedure |
Pancreatico-duodenectomy |
440 |
302 |
1 |
|
0.06 |
| |
Distal pancreatectomy |
106 |
58 |
0.82 |
0.62 – 1.09 |
|
| |
Total pancreatectomy |
74 |
52 |
1.33 |
0.99 – 1.78 |
|
| Grading |
G1 |
19 |
9 |
0.38 |
0.20 – 0.74 |
<0.0001 |
| |
G2 |
419 |
267 |
1 |
|
|
| |
G3 |
178 |
132 |
1.51 |
1.23 – 1.87 |
|
| Resection margin |
Negative |
329 |
232 |
1 |
|
0.0251 |
| |
Positive |
287 |
177 |
1.25 |
1.03 – 1.53 |
|
| CA 19–9 [U/ml] |
<37 |
127 |
68 |
1 |
|
0.0002 |
| |
≥37 |
453 |
316 |
1.65 |
1.27 – 2.14 |
|
| Blood group |
A |
324 |
228 |
1 |
|
0.39 |
| |
AB |
29 |
17 |
0.76 |
0.47 – 1.25 |
|
| |
B |
73 |
46 |
0.89 |
0.65 – 1.23 |
|
| |
O |
194 |
121 |
0.85 |
0.68 – 1.06 |
|
| Blood group |
A/B/AB |
426 |
291 |
1 |
|
0.23 |
| |
O |
194 |
121 |
0.88 |
0.71 – 1.09 |
|
| Rhesus factor |
Positive |
514 |
340 |
1 |
|
0.74 |
| Negative | 106 | 72 | 0.96 | 0.74 – 1.24 |
Analyses include 620 patients with R0/1 pancreatic resection for ductal adenocarcinoma of the pancreas (7 patients with incomplete follow-up excluded). HR, hazard ratio; CI; confidence interval.