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Effect of sorafenib onapoptosis of irradiated HCCcells. Sorafenib promoted apoptosis of hepatocellular carcinoma (HCC) cells with or without radiation but had no delaying effect. Cells were treated with 15 μM sorafenib for 30 min prior to 6 Gy irradiation. (A) SMMC-7712 cells. (B) BEL-7402 cells. Cells were collected at indicated times after the last treatment, and stained with Annexin V-FITC and propidium iodide. Mean ± SEM of three independent experiments.
