Table 1.

Glossary of abbreviations.

fa	Fraction of viruses or infection events affected by the drug
fu	Fraction of viruses or infection events unaffected by the drug
[D]	Drug concentration
IC50	Drug concentration that leads to 50% inhibition
m	Slope parameter or Hill coefficient
Kd	Dissociation constant for a drug binding to an individual target enzyme molecule
nT	Average of total number of enzyme molecules per virion relevant to the inhibited reaction
c	Critical threshold number of functional enzyme molecules required for viral replication
[V]	Unbound virus concentration
σ	Standard deviation for nT
nmax	Maximum total number of enzyme molecules per virion, usually set as > nT + 3σ
ni	Given total number of enzyme molecules per virion relevant to the inhibited reaction
fm	Fraction of mutant plasmid transfected
Pf	Probability of obtaining functional enzyme multimers for a given fm
nF	Total number of functional target molecules per virion relevant to the inhibited reaction
RI	Relative infectivity of phenotypically-mixed viruses compared to the wild type virus