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. Author manuscript; available in PMC: 2012 Nov 4.
Published in final edited form as: Clin Pharmacol Ther. 2007 May 9;83(1):77–85. doi: 10.1038/sj.clpt.6100230

Table III.

Amounts of conjugated itraconazole (ITZ), ND-ITZ and the free and conjugated hydroxy-itraconazole (OH-ITZ) excreted into urine during the 24 hour dosing interval on day 1 and day 7 of the study. The β-glucuronidase used has sulfatase activity as well and thus it is possible that some of the cleaved conjugates were sulfates instead of glucuronides.

ITZ-conjugate (nmol) ND-ITZ-conjugate (nmol) OH-ITZ-conjugate (nmol) OH-ITZ (nmol) Total OH-ITZ (nmol)
Day 1 6 ± 6 9 ± 6 40 ± 17 59 ± 44 100 ± 49
Day 7 19 ± 15 4 ± 4 204 ± 89 62 ± 31 266 ± 90