Scheme 2.
Reagents and condition: a) BuLi/−78 °C, RT/16 h, 95-98%; b) DCM/24 h 60-70%; c) DMF, 0 °C-RT/5 h, 3:1:3 DMG/H2O/MeOH, NaBH4/16 h, 25-40%.
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