Skip to main content
. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Chem Biol Drug Des. 2013 Apr;81(4):10.1111/cbdd.1427. doi: 10.1111/cbdd.1427

Scheme 3.

Scheme 3

Reagents and conditions. a) BuLi/−78 °C, RT/16 h, 95-98%; b) DCM/24 h, 60-70%; c) DCM/24 h, 70-80%; d) DMG/0 °C-RT/5 h, 3:1:3 DMF/H2O/MeOH, NaBH4/16 h, 25-45%.