Table 2.

In vitro antileishmanial activity (L. donovani) of tricyclic guanidine derivatives

Compd. No.	L. donovani		Compd. No	L. donovani
	IC50 (μM)	IC90 (μM)		IC50 (μM)	IC90 (μM)
12a	64.98	126	17b	14.44	29.65
12b	12.31	33.03	17c	10.13	23.85
12c	2.39	11.27	17d	59.60	112.5
12d	48.25	91.15	17e	85.69	>13
12e	73.26	>130	17f	61.06	125
12f	28.87	91.18	17h	63.09	>100
12h	29.47	72.56	17i	63.75	>100
12i	32.41	79.80	17j	62.91	>100
12j	29.34	78.24	17l	48.19	124.4
12l	13.33	55.73	20a	29.31	116
14a	34.02	106.5	20b	57.76	119
14b	9.51	19.59	20c	10.34	22.25
14c	2.78	12.76	20d	57.23	114
14d	46.51	93.02	20e	133.6	>100
14e	62.71	128.9	20f	50.90	>100
14f	10.20	20.40	20h	12.08	45.31
14h	7.23	14.91	20i	48.23	106
14i	7.71	15.90	20l	9.52	20.95
14l	10.97	21.94

IC₅₀ and IC₉₀ = Sample concentrations that kill 50% and 90% cells compared to the solvent controls; Pentamidine: IC₅₀ = 2.94 μM, IC₉₀ = 5.88 μM; Amphotericin B: IC₅₀ = 0.173 μM, IC₉₀ = 0.358 μM.