Table 2.

Tissue reaction at sacrifice following i.m. administration of C-TT2-CTP35 vaccine formulations in rabbits, evaluated by a macroscopic scoring system as described in Section 2.9.

Groupa	Score of tissue reaction		Time of sacrifice
	Mean ± S.E.	Range
I	0.0 ± 0.0	0 – 0	24 weeks
II	0.4 ± 0.2	0 – 0.5	24 weeks
III	0.7 ± 0.4	0 – 1	24 weeks
IV	0.0 ± 0.0	0 – 0	24 weeks
V	0.5 ± 0.0	0.5 – 0.5	24 weeks
VI	1.9 ± 0.2	1.5 – 2	24 weeks
VII	0.0 ± 0.0	0 – 0	24 weeks
VIII	0.0 ± 0.0b	0 – 0	24 weeks
Blankc	0.5 ± 0.0	0.5 – 0.5	4 weeks
Blank/MgCO3d	0.9 ± 0.2	0.75 – 1	4 weeks

^aGroups I-VIII are as described in Table 1.

^bn = 4. Another group of rabbit (n = 2) sacrificed at antibody peak time, 10 weeks, showed a score of 0.8 ± 0.4 with a range of 0.5 – 1.

^cBlank microspheres. Neither antigen nor MgCO₃ was encapsulated; n = 2.

^dBlank microspheres with 3% MgCO₃; n = 2.