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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Apr 13;22(11):3739–3742. doi: 10.1016/j.bmcl.2012.04.023

Scheme 2.

Scheme 2

Modifications to C-3 Ester

Reagents and Conditions: (a) LiBH4, MeOH; (b) R1Br, NaH or R1OH, PPh3, DIAD or AcCl, pyr; (c) LiOH, THF; (d) R4NH2, HATU, DIEA; (e) 1. (PhO)2P(O)(N3), PPh3, THF; 2 Pd/C, H2; (f) R2OCOCl or R3SO2Cl, Et3N or R2CHO, NaBH(OAc)3.

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