Table 1.

Tertiary amine TIQ Rev-erbα agonists

Compound	R	a Max Inh	EC50 (μM)
1		0.82	2.3
3a		0.78	b NT
3b		1.0	NT
3c		0.90	NT
3d		1.0	NT
3e		1.0	NT
3f		0.95	NT

^aresults are average of 2 or more experiments. Value = fold change relative to DMSO control at 10 μM compound. The lower the number, the more efficacious the agonist in terms of repressing transcription;

^bNT = not tested.