. Author manuscript; available in PMC: 2013 Jun 1.

Published in final edited form as: Bioorg Med Chem Lett. 2012 Apr 13;22(11):3739–3742. doi: 10.1016/j.bmcl.2012.04.023

Table 2.

Tertiary TIQ amides as Rev-erbα agonists


Compound	R	^a Max Inh	EC₅₀ (μM)
3g		0.64	^b NT
3h		0.73	NT
3i		0.51	>3.0
3j		0.81	NT
3k		0.97	NT
3l		0.78	NT
3m		0.97	NT
3n		1.0	NT
3o		0.41	2.5
3p		0.53	2.1

results are average of 2 or more experiments. Value = fold change relative to DMSO control at 10 μM compound. The lower the number, the more efficacious the agonist in terms of repressing transcription;

NT = not tested.