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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Apr 13;22(11):3739–3742. doi: 10.1016/j.bmcl.2012.04.023

Table 3.

Sulfonamide, carbamate and urea TIQ Rev-erbα agonists

graphic file with name nihms412702u3.jpg
Compound R a Max Inh EC50 (μM)
3q graphic file with name nihms412702t17.jpg 0.75 b NT
3r graphic file with name nihms412702t18.jpg 0.50 1.7
3s graphic file with name nihms412702t19.jpg 0.51 1.1
3t graphic file with name nihms412702t20.jpg 1.0 NT
3u graphic file with name nihms412702t21.jpg 1.3 NT
3v graphic file with name nihms412702t22.jpg 1.0 NT
3w graphic file with name nihms412702t23.jpg 1.5 NT
3x graphic file with name nihms412702t24.jpg 1.0 NT
a

results are average of 2 or more experiments. Value = fold change relative to DMSO control at 10 μM compound. The lower the number, the more efficacious the agonist in terms of repressing transcription;

b

NT = not tested.

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