Table 2.
The most recurrent chromosomal aberrations detected by BAC CGH-array in a panel of 28 SPRD-CU3 DMBA-induced mammary tumors
| RNO | Position (Mb) in the rat genome | Rat position | Homologous position in human | Frequency |
|---|---|---|---|---|
|
Loss |
|
|
|
|
| 5q |
~108 |
5q32 |
9p21 |
20 (71%) |
| 6q |
~60-66 |
6q21 |
14q12, 7q22 |
15 (53%) |
| 4q |
~38-43 |
4q21 |
7p21, 7p31 |
6 (21%) |
| 20q |
~49-telomere |
20q13 |
6q21 |
4 (41%) |
|
Gain |
|
|
|
|
| 12q |
~15 |
12q11 |
7p22 |
15 (53%) |
| 20q |
~44 |
20q12 |
6q21 |
14 (50%) |
| 20p |
~15 |
20p11 |
10q21 |
12 (43%) |
| 20p |
~3 |
20p12 |
UN |
11 (39%) |
| 10q |
~54 |
10q24 |
17p13 |
11 (39%) |
| 10q |
~13 |
10q12 |
16p13 |
8 (28%) |
| 12q | ~44 | 12q16 | 12q24 | 5 (18%) |
Based on Human 35 and Rat RGSC v3.4 genome build.