Table 3.
Change in physical and psychosocial symptom burden within chemotherapy lines
|
EORTC QLQ-C30 |
Adjuvant CT |
1st pall. CT |
2nd pall. CT |
3rd+pall. CT |
||||
|---|---|---|---|---|---|---|---|---|
| monthly change rate | p | monthly change rate | p | monthly change rate | p | monthly change rate | p | |
|
Physical Functioning |
3.3 |
<0.001 |
−0.1 |
0.868 |
−1.2 |
0.087 |
−3.0 |
0.001 |
| Role Functioning |
6.8 |
<0.001 |
0.0 |
0.994 |
−1.7 |
0.059 |
−3.2 |
0.002 |
| Social Functioning |
1.9 |
0.135 |
1.1 |
0.071 |
−1.1 |
0.110 |
−2.1 |
0.019 |
| Emotional Functioning |
1.8 |
0.006 |
0.6 |
0.301 |
−0.5 |
0.299 |
−2.3 |
0.001 |
| Cognitive Functioning |
−0.1 |
0.901 |
0.1 |
0.859 |
−1.2 |
0.036 |
−1.4 |
0.200 |
| Global QOL |
4.1 |
<0.001 |
0.0 |
0.955 |
−0.9 |
0.166 |
−1.6 |
0.012 |
| Fatigue |
−3.4 |
0.009 |
0.0 |
0.992 |
1.3 |
0.117 |
3.3 |
0.002 |
| Pain |
−1.1 |
0.128 |
−0.1 |
0.902 |
0.0 |
0.952 |
0.6 |
0.394 |
| Nausea/Vomiting |
−2.4 |
0.006 |
−0.9 |
0.162 |
−0.6 |
0.450 |
2.0 |
0.105 |
| Dyspnoea |
−0.5 |
0.494 |
0.4 |
0.476 |
0.6 |
0.506 |
4.6 |
0.006 |
| Appetite Loss |
−1.8 |
0.067 |
−0.2 |
0.802 |
−0.7 |
0.341 |
3.0 |
0.030 |
| Sleeping Disturbances |
−4.3 |
0.022 |
−1.2 |
0.182 |
0.9 |
0.358 |
2.0 |
0.055 |
| Constipation |
−1.7 |
0.217 |
−1.2 |
0.171 |
−0.5 |
0.380 |
−1.0 |
0.202 |
| Diarrhoea |
0.0 |
0.986 |
−0.4 |
0.445 |
0.9 |
0.221 |
0.1 |
0.911 |
| Financial Impact |
0.7 |
0.593 |
0.5 |
0.322 |
0.4 |
0.550 |
2.4 |
0.017 |
| Taste Alterations | 1.9 | 0.123 | 1.8 | 0.012 | 1.1 | 0.136 | −0.3 | 0.749 |
* Monthly change rates give change estimates in score points per 30 days, based on the mixed effect model.