Table 3.
Cox univariate and multivariate analysis of distant disease-free survival
| |
Univariate analysis (n ≤ 401) |
Multivariate analysis (n = 377) |
||||
|---|---|---|---|---|---|---|
| Variable | HR* | 95% CI | p-value | HR** | 95% CI | p-value |
|
DTC status (IF and IC) (n=401) DTC+ vs DTC- |
1.2 |
0.66-2.2 |
0.55 |
|
|
|
|
DTC status (IF) (n=327) |
1.2 |
0.63- 2.2 |
0.60 |
|
|
|
| DTC+ vs DTC- |
|
|
|
|||
|
DTC statuc (IC) (n=74) DTC+ vs DTC- |
0.84 |
0.09-8.1 |
0.88 |
|
|
|
|
Age |
0.99 |
0.97-1.02 |
0.61 |
|
|
|
| per year |
|
|
|
|||
|
Node status |
5.5 |
2.7- 11 |
< 0.001 |
3.4 |
1.6- 7.2 |
0.001 |
| N+ vs N0 | ||||||
|
Tumor size |
4.9 |
2.6-9.4 |
< 0.001 |
2.5 |
1.2- 5.2 |
0.01 |
| > 20 mm vs ≤ 20 mm | ||||||
|
NHG status |
6.9 |
0.92-52 |
0.06 |
4.9 |
0.65-37 |
0.12 |
| NHG 2 vs NHG 1 | ||||||
| NHG 3 vs NHG 1 |
20 |
2.7- 147 |
0.004 |
8.7 |
1.1- 70 |
0.04 |
|
ER status |
0.39 |
0.21-0.72 |
0.003 |
0.85 |
0.38- 1.9 |
0.7 |
| ER+ vs ER- | ||||||
|
PR status |
0.43 |
0.24- 0.79 |
0.007 |
0.67 |
0.33- 1.4 |
0.3 |
| PR+ vs PR- | ||||||
* No significant deviations from proportional hazards (Schoenfeld’s test).
* *P=0.05 in Schoenfeld’s global six degree-of-freedom test of proportional hazards.
Abbreviations: IF= immunofluorescence, IC=immunocytochemistry, HR= hazard ratio, CI= confidence interval, DTC= disseminated tumor cells, N0= node negative, N+= node positive, NHG= Nottingham histological grade, ER= oestrogen receptor, PR= progesterone receptor.