Table 1.

Chromosome imbalance regions in lung cancer (alteration frequency > 50%)

Chromosome	Cytobanda	Start siteb	End siteb	Size (Mb)c	BAC number	Alteration frequency (n=40)	Gene numberd
A. Asian
3	p13-14.1*	64934270	73536726	8.60	74	Gain: 73%	23
6	p22.1*	26562439	28452189	1.89	60	Gain: 70%	31
9	q21.13*	73445866	76242707	2.80	29	Gain: 70%	8
10	q21.3	69354590	71006065	1.65	15	Gain: 55%	23
10	q24.1	95664566	99431796	3.77	37	Gain: 58%	44
12	p13.31-13.32	2363194	8268165	5.90	44	Gain: 60%	58
13	q14.1-14.2*	42340030	47097431	4.76	38	Gain: 80%	22
17	p13.3*	373082	2754327	2.38	20	Gain: 60%	37
2	p23.2-23.3	25035233	33995335	8.96	75	Loss: 63%	83
2	p24.1	21212355	23783250	2.57	18	Loss: 58%	1
2	q35	215083214	215870969	0.79	9	Loss: 58%	5
3	p21.3-22.3*	33902686	44181635	10.28	82	Loss: 65%	90
4	p15.2-15.31	22255381	24549727	2.29	24	Loss: 60%	5
6	p22.2	23982002	25939112	1.96	68	Loss: 80%	16
12	q15	67646357	69188647	1.54	11	Loss: 55%	11
13	q13.3*	35856763	39003721	3.15	27	Loss: 65%	18
X	p22.31	5701499	5872842	0.17	2	Loss: 50%	1
Overall							476
B. Caucasian
2	p24.1-24.3	12723105	21045423	8.32	58	Gain: 55%	21
2	q25.1	11704089	12544967	0.84	7	Gain: 50%	2
3	p12.3-13*	67690502	79574641	11.88	96	Gain: 70%	22
3	p14.1-14.3*	56804094	67550231	10.75	65	Gain: 50%	26
3	p21.31-22.1	42559388	46459596	3.90	33	Gain: 60%	57
3	p25.3-26.3	1711179	9591700	7.88	72	Gain: 55%	20
6	p22.1-22.3*	20951128	28567815	7.62	132	Gain: 60%	97
9	q21.13*	75834015	76513536	0.68	6	Gain: 70%	5
13	q14.1-14.2*	40944092	47097431	6.15	47	Gain: 80%	24
17	p13.2-13.3*	481074	4001084	3.52	13	Gain: 70%	35
X	p22.11-22.2	16180300	22691476	6.51	49	Gain: 60%	26
2	p22.3	32854381	33890229	1.04	6	Loss: 50%	3
2	p24.3-25.1	31026798	31813698	0.79	6	Loss: 50%	3
3	p11.1-12.1	84572959	90247330	5.67	46	Loss: 70%	9
3	p22.2-22.3*	32980614	36795763	3.82	13	Loss: 75%	14
3	p23	31259835	32891762	1.63	13	Loss: 60%	10
6	p21.2-22.1	29049491	39602226	10.55	86	Loss: 70%	27
10	p23.1-23.2	82106537	89500949	7.39	79	Loss: 60%	36
12	p12.31	8090287	9190860	1.10	7	Loss: 50%	18
13	q13.3*	35856763	36315193	0.46	5	Loss: 80%	4
Overall							459

^a The common alteration regions in both Asian and Caucasian are marked with asterisk (*).

^b The information of cytoband start site and end site nucleotide sequences were from UCSC database (http://genome.ucsc.edu/, build 36 - hg18).

^c The sizes of cytoband were calculated from the start site to the end site nucleotide sequences.

^d The gene number of candidate genes was estimated by “NimbleGen: Transcription_Start_Sites.gff” annotation file (Roche, Palo Alto, CA). The annotation file indicates all transcription initiation sites for build hg18 as reported in the UCSC Genome browser.