Table 2.

Members of the International Knockout Mouse Consortium (IKMC)

Member	Role
International Knockout Mouse Consortium (IKMC)	Enables the IKMC database to be searched for a gene of interest by gene symbols, gene IDs or genome location. Provides information on availability of knockout attempts and other resources. Incorporates information from all the partners and provides a “one stop shop” for information on knockouts for your gene of interest.
http://www.knockoutmouse.org/
NIH Knockout Mouse Project (KOMP)	Incorporates KOMP-CSD and KOMP-Regeneron, Inc.
http://www.nih.gov/science/models/mouse/knockout/	KOMP-CSD use promoterless and promoter-driven targeting cassettes to make a 'Knockout-first allele' and produce frame shift mutations of a ‘critical’ exon.
	KOMP-Regeneron Velocogene constructs generate complete null alleles that delete the entire protein coding sequence of the target gene.
	Provides central database resource through the Knockout Mouse Project Data Coordination Centre (KOMP DCC).
	KOMP Repository to archive, maintain and distribute KOMP products.
The European Conditional Mouse Mutagenesis Program (EUCOMM)	Uses conditional gene targeting and trapping approaches to generate 12,000 conditional mutants as ES cells.
www.eucomm.org/
North American Conditional Mouse Mutagenesis project (NorCOMM)	Utilizes a combination of gene trap random mutagenesis and systematic high-throughput targeting of remaining un-trapped genes.
http://www.norcomm.org/index.htm
Texas A&M Institute for Genomic Medicine (TIGM)	A huge resource of over 350,000 gene trap C57BL/6N
http://www.tigm.org/	ES cell lines for more than 13,000 mouse genes.
	In addition holds 270,000 sequence-tagged 129/SvEvBrd gene trap embryonic stem cell clones.