TABLE 1.
SIGNIFICANT SINGLE-NUCLEOTIDE POLYMORPHISMS IDENTIFIED BY HAPLOTYPE ASSOCIATION MAPPING OF VENTILATOR-INDUCED LUNG INJURY IN MICE
| Chromosome | Position | dbSNP | Region | Alleles | −log (P) | Symbol |
| 1 | 181141730 | rs32601567 | Intron | C/T | 6.75 | Smyd3 |
| 1 | 181145346 | rs31517246 | Intron | A/G | 6.08 | Smyd3 |
| 1 | 181167686 | rs32357487 | Intron | A/G | 6.75 | Smyd3 |
| 1 | 181254194 | rs32370428 | Intron | C/T | 6.75 | Smyd3 |
| 1 | 181254863 | rs32390461 | Intron | A/G | 6.75 | Smyd3 |
| 1 | 181330284 | rs13476264 | Intron | C/T | 6.87 | Smyd3 |
| 1 | 181970809 | rs32668729 | Intron | C/T | 6.84 | Cdc42bpa |
| 1 | 189141678 | rs31931745 | Intron | A/G | 6.45 | Gpatch2 |
| 3 | 75255647 | rs13477201 | Coding | C/T | 7.01 | Wdr49 |
| 4 | 119751327 | rs6401898 | Intron | A/G | 6.12 | Hivep3 |
| 5 | 65197908 | rs33714346 | Intron | C/T | 7.23 | Klf3 |
| 5 | 142665148 | rs33587040 | Intron | A/G | 6.34 | Sdk1 |
| 6 | 45945581 | rs30354170 | Intron | C/T | 6.02 | Cntnap2 |
| 7 | 131322893 | rs31985864 | Intron | C/T | 6.41 | Hs3st4 |
| 11 | 4442382 | rs29417270 | Intron | A/G | 9.12 | Mtmr3 |
| 11 | 4447839 | rs26938982 | Intron | A/C | 8.69 | Mtmr3 |
| 11 | 4470221 | rs26923056 | Intron | A/G | 8.69 | Mtmr3 |
| 11 | 4552514 | rs29438722 | Intron | A/T | 6.50 | Ascc2 |
| 11 | 30780223 | rs13467861 | 3′ UTR | A/T | 6.17 | Psme4 |
| 15 | 64110550 | rs31110351 | Intron | C/G | 6.02 | Asap1 |
| 15 | 64129266 | rs6177246 | Intron | A/T | 7.23 | Asap1 |
| 15 | 64129349 | rs6177728 | Intron | C/T | 6.64 | Asap1 |
| 15 | 64169932 | rs31589408 | Intron | A/C | 6.64 | Asap1 |
| 15 | 64579156 | rs31127725 | Intron | C/G | 9.40 | Adcy8 |
| 15 | 64579327 | rs31127727 | Intron | C/T | 9.40 | Adcy8 |
| 15 | 64624571 | rs31131314 | Intron | A/G | 9.40 | Adcy8 |
| 15 | 64646875 | rs13482616 | Coding | C/T | 9.51 | Adcy8 |
| 15 | 64685909 | rs32478823 | Intron | A/T | 9.40 | Adcy8 |
| 15 | 66752215 | rs13482623 | 3′ UTR | C/T | 7.39 | Wisp1 |
| 15 | 66791317 | rs31744623 | Intron | C/G | 8.10 | Ndrg1 |
| 15 | 66792183 | rs31588658 | Intron | A/G | 7.23 | Ndrg1 |
| 16 | 41868185 | rs4178707 | Intron | C/T | 8.62 | Lsamp |
| 19 | 50686324 | rs30420148 | Intron | C/T | 6.23 | Sorcs1 |
Definition of abbreviations: Adcy8, Adenylate cyclase 8; Asap1, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1; Ascc2, activating signal cointegrator 1 complex subunit 2; Cdc42bpa, CDC42 binding protein kinase alpha; Cntnap2, contactin associated protein-like 2; dbSNP, National Center for Biotechnology Information single-nucleotide polymorphism identification number; Gpatch2, G patch domain containing 2; Hivep3, human immunodeficiency virus type I enhancer binding protein 3; Hs3st4, heparan sulfate (glucosamine) 3-O-sulfotransferase 4; Klf3, Kruppel-like factor 3 (basic); −log(P), negative log of the probability; Lsamp, limbic system-associated membrane protein; Mtmr3, myotubularin related protein 3; Ndrg1, N-myc downstream regulated gene 1; Position, basepair location of gene; Psme4, proteasome (prosome; macropain) activator subunit 4; Sdk1, sidekick homolog 1 (chicken); Smyd3, SET and MYND domain containing 3; Sorcs1, Sortilin-related VPS10 domain containing receptor 3; UTR, untranslated region; Wdr49, WD repeat domain 49; Wisp1, WNT1-inducible signaling pathway protein 1.