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Lineage tracing by the colocalization of FoxJ1 (red) and LacZ (green) in the Rosa–CebpαΔ/Δ mice on Day 5 after naphthalene injury. In the Rosa–control mice terminal bronchioles, FoxJ1/LacZ double-positive cells were detected 5 days after naphthalene injury (arrows). Double-positive cells were rarely seen in the Rosa–CebpαΔ/Δ mice 5 days after naphthalene injury, demonstrating decreased cell differentiation of the progenitor cells to ciliated cells. Scale bars, 20 μm (n = 3/group).
