Figure 6.

(A) PLY (3.125 μg/kg, intratracheally) induces pulmonary endothelial hyperpermeability within 6 hours in male C57BL6 mice. Upon cotreatment, the specific PKC-α inhibitor Ro32–4032 (49.5 μg/kg) and the TIP peptide (2.5 mg/kg) significantly blunt this activity (n = 6). (B) A^+/−/^−/− C57BL/6 mice, which have a 10-fold lower expression of arginase I in the lungs, as compared with wt mice (C), but not A^+/+/^−/− mice, are significantly protected from PLY (3.125 μg/kg)-induced hyperpermeability (n = 6).