Figure 2.

Enhanced IDO reduces Th1 and Th2 cytokine concentrations in lung allografts. Enhanced IDO significantly reduced the alloantigen-specific production of Th1-related and Th2-related cytokines, including IFN-γ (A), TNF-α (B), IL-2 (C), IL-12 (D), IL-4 (E), IL-5 (F), IL-13 (H), IL-6 (I), and IL-17 (J) in lung grafts. Concentrations of IL-10 (G) and IL-17 (J) were not affected by IDO. Results are presented as means ± SEM (n ≥ 4 in each group). *P < 0.05 and **P < 0.01, versus all other allograft groups.