Figure 3.

Examples of hemodynamic data obtained in a pig treated with inert vehicle that developed RV pulsus alternans near the end of 4 hours of RVPO. Prominent alterations of RV pressure, RV free wall contraction, and pulmonary artery (PA) flow occurred. The minimal concurrent alternation of left ventricular (LV) pressure was likely attributable to interventricular interactions. The electrocardiogram (ECG) indicates atrial paced rhythm. Treatment with MDL-28170, compared with vehicle, reduced the incidence of RV pulsus alternans (52% versus 20%, respectively; P = 0.056).