TABLE 2.
REGIONAL HEMODYNAMICS
| Baseline | Infusion | RVPO (20 min) | RVPO (4 h) | Recovery (20 min) | |
| Regional external work (fraction of baseline): P = 0.033 for MDL-28170 versus vehicle | |||||
| Vehicle | 1 | 0.98 ± 0.03 | 1.55 ± 0.13 | 0.56 ± 0.07 | 0.50 ± 0.06 |
| MDL-28170 | 1 | 0.98 ± 0.04 | 1.67 ± 0.11 | 0.73 ± 0.05* | 0.55 ± 0.04 |
| End-diastolic area (fraction of baseline) | |||||
| Vehicle | 1 | 1.00 ± 0.01 | 1.18 ± 0.04 | 1.05 ± 0.06 | 1.08 ± 0.06 |
| MDL-28170 | 1 | 1.00 ± 0.02 | 1.19 ± 0.07 | 1.04 ± 0.05 | 1.00 ± 0.04 |
| Regional Frank–Starling relation slope (fraction of baseline) | |||||
| Vehicle | 1 | 1.01 ± 0.02 | 0.68 ± 0.06 | ||
| MDL-28170 | 1 | 1.06 ± 0.05 | 0.89 ± 0.07† | ||
| Regional Frank–Starling Relation intercept (fraction of baseline) | |||||
| Vehicle | 1 | 1.01 ± 0.01 | 1.18 ± 0.07 | ||
| MDL-28170 | 1 | 1.02 ± 0.01 | 1.15 ± 0.04 | ||
| Regional external work normalized to baseline at matched end-diastolic area | |||||
| Vehicle | 1 | 0.98 ± 0.02 | 0.45 ± 0.12 | ||
| MDL-28170 | 1 | 0.99 ± 0.03 | 0.55 ± 0.09 | ||
All values represent means ± SEM.
*
P = 0.020 for vehicle pigs versus MDL-28170 pigs.
†
For regional Frank–Starling slope normalized to baseline value, P = 0.020 for vehicle pigs versus MDL-28170 pigs. Indices derived from the Frank–Starling relation were not determined during RVPO because IVC occlusion during severe RVPO results in hemodynamic instability.