Table 1.
Multivariate model with hazard ratios for time to GVHD, time to TRM, and overall survival using day TNFR1 ratio threshold (>2.5) [from reference 19]
| GVHD | TRM | Overall survival | |||||
|---|---|---|---|---|---|---|---|
| Variable | Category | HR | P | HR | P | HR | p |
| Day 7 TNFR1 ratio | ≤2.5 | Ref | - | Ref | - | Ref | - |
| >2.5 | 2.44 | <0.001 | 2.40 | <0.001 | 1.39 | 0.03 | |
| Donor type | Related | Ref | - | Ref | - | Ref | - |
| Unrelated | 1.87 | <0.001 | 3.25 | <0.001 | 1.49 | 0.006 | |
| HLA-matched | Yes | Ref | - | Ref | - | Ref | - |
| No | 1.93 | 0.01 | 1.09 | 0.79 | 1.25 | 0.28 | |
| Recipient age* | 1.05 | 0.35 | 1.28 | 0.002 | 1.10 | 0.03 | |
| Donor/recipient gender | Male/male | Ref | - | Ref | - | Ref | - |
| Female/male | 1.29 | 0.19 | 1.26 | 0.39 | 1.02 | 0.90 | |
| Male/female | 0.63 | 0.04 | 0.69 | 0.19 | 0.88 | 0.46 | |
| Female/female | 0.80 | 0.54 | 0.75 | 0.57 | 1.01 | 0.98 | |
| Disease** | Nonmalignant | Ref | - | Ref | - | Ref | - |
| Standard risk | 1.65 | 0.36 | 0.96 | 0.96 | 4.26 | 0.05 | |
| Advanced risk | 1.74 | 0.31 | 1.31 | 0.70 | 7.67 | 0.005 | |
| Conditioning regimen | Non-TBI | Ref | - | Ref | - | Ref | - |
| TBI | 1.14 | 0.63 | 0.61 | 0.20 | 1.18 | 0.45 | |
TBI = total body irradiation
*
For recipient age, HR reflects the change in hazard for every ten years
**
Standard risk: lymphoma with chemosensitive disease, leukemia in complete remission, or untreated myelodysplastic syndrome. Advanced risk: leukemia not in remission, lymphoma with stable or progressive disease at time of transplantation