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Trimodal HMOX1 (GT)n repeat distribution among 942 participants with SCD in the SIT Trial. Allele lengths were scored as number of dinucleotide repeats and ranged from 13 to 45 repeats. Individual (GT)n alleles assigned to −413 T (gray bars) or A (black bars) chromosomes by PHASE 2.1 haplotype estimation. Initial analyses were performed by grouping observed HMOX1 (GT)n repeat sizes into 2 allele classes: short (S) with ≤ 25 repeats and long (L) with > 25 repeats.
