Table 4.

Factors associated with vaso-occlusive crises in the SIT Trial

Covariate	ACS		Pain
	Rate	P	Rate	P
% fetal hemoglobin*		< .0001		.23
Sex
Male	0.17	.005	0.68	.07
Female	0.12		0.58
Asthma diagnosis
Yes	0.21	< .0001	0.74	.02
No	0.12		0.59
α-globin genotype†
αα/αα	0.15		0.56
α/αα	0.14	.41	0.69	.03
α/-α	0.08	.07	0.88	.02

^*P values derived from the regression of ACS or pain on the log transformation of fetal hemoglobin.

^†Persons with αα/ααα genotypes carried no gene deletions and were grouped with αα/αα for analysis.