a. Acute spontaneous urticaria |
ns sg H1-AH: l |
Low |
Strong |
Prednisolone, 2 × 20 mg/d* for 4 days |
Low |
Weak |
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Prednisolone, 50 mg/d* for 3 days |
Very low |
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H2-blocker, single dose for 5 days |
Very low |
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b. Chronic spontaneous urticarial |
ns sg H1-AH |
High |
Strong |
ns sg H1-AH and ciclosporin |
High |
All weak |
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ns sg H1 and H2-AH cimetidine |
Very low |
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- Increase dosage if necessary up to fourfold |
Low |
Weak |
Monotherapy: |
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Tricyclic antidepressants (doxepin) |
Low |
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Ketotifen |
Low |
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Hydroxychloroquine |
Very low |
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Dapsone |
Very low |
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Sulfasalazine |
Very low |
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Methotrexate |
Very low |
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Corticosteroids |
Very low |
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Other treatment options |
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Combination therapy: |
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ns sg H1-AH and stanazolol |
Low |
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ns sg H1-AH and zafirlukast |
Very low |
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ns sg H1-AH and mycophenolate mofetil |
Very low |
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ns sg H1-AH and narrowband UV-B |
Very low |
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ns sg H1-AH and omalizumab |
Very low |
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Monotherapy: |
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Oxatomide |
Very low |
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Nifedipine |
Very low |
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Warfarin |
Very low |
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Interferon |
Very low |
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Plasmapheresis |
Very low |
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Immunoglobulins |
Very low |
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Autologous whole blood injection |
Very low |
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(ASST positive only) |
c. Physical urticaria |
In generel for physical urticarias: |
High |
Strong |
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Very low |
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Avoidance of stimuli |
Symptomatic dermographism/Urticaria factitia |
ns sg H1-AH: |
Low |
Weak |
Ketotifen (see also chronic urticaria) narrowband UV-B therapy |
Very low |
All weak |
Delayed pressure |
ns sg H1-AH: cetirizine |
Low |
All weak |
Combination therapy: |
All weak |
urticaria |
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Montelukast and ns H1-AH (loratadine) |
Very low |
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High dose ns H1-AH |
Very low |
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Monotherapy: |
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Very low |
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Prednisolone 40-20 mg* |
Very low |
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Other treatment options |
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Combination therapy: |
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Ketotifen and nimesulide |
Very low |
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Monotherapy:Topical clobetasol propionate. |
Very low |
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Sulfasalazine |
Very low |
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Cold urticaria |
ns sg H1-AH |
High |
Strong |
Trial with penicillin i.m./p.o. |
Very low |
All weak |
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Trial with doxycyline p.o. |
Very low |
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Increase dose up to fourfold |
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Induction of physical tolerance |
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Other treatment options |
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Cyproheptadine |
Very low |
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Ketotifen |
Low |
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Montelukast |
Very low |
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Solar urticaria |
ns H1-AH |
Very low |
Weak |
Induction of physical tolerance |
Very low |
All weak |
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Other treatment options |
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Plasmapheresis + PUVA |
Very low |
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Photopheresis |
Very low |
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Plasma exchange |
Very low |
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IVIGs |
Very low |
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Omalizumab |
Very low |
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d. Special types of inducible urticaria |
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Cholinergic urticaria |
ns H1-AH |
Low |
Weak |
"Exercise tolerance" |
Very low |
All weak |
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Other treatment options |
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- Increase dosage if necessary, up to fourfold |
Low |
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Ketotifen, danazol |
Very low |
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Omalizumab |
Very low |
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