Table 1.
Baseline characteristics of 11,776 dialysis patients who underwent renal transplantation between July 2001 and June 2006
| Pretransplant Serum Alkaline Phosphatase (U/L) | <80 | 80–<120 | 120–<160 | ≥160 | P for Trend |
|---|---|---|---|---|---|
| n (%) | 3769 (32) | 4701 (40) | 1833 (16) | 1473 (12) | N/A |
| Age (yr) | 48±14 | 48±14 | 47±14 | 42±16 | <0.001 |
| Female sex | 34 | 40 | 45 | 47 | <0.001 |
| Race (% African American) | 24 | 26 | 28 | 31 | <0.001 |
| Diabetes mellitus | 28 | 36 | 41 | 35 | <0.001 |
| Proportion of peritoneal dialysis patients | 18 | 17 | 17 | 20 | 0.07 |
| BMI (kg/m2) | 26.8±5.8 | 26.6±5.8 | 26.4±5.7 | 25.5±6.4 | <0.001 |
| Presence of ischemic heart disease | 8 | 9 | 9 | 7 | 0.24 |
| Presence of congestive heart failure | 8 | 10 | 12 | 10 | <0.001 |
| Presence of hypertension | 78 | 77 | 75 | 68 | <0.001 |
| Presence of cerebrovascular events | 2 | 3 | 2 | 2 | 0.60 |
| Presence of peripheral vascular disease | 3 | 4 | 4 | 4 | 0.02 |
| Presence of chronic obstructive pulmonary disease | 1 | 1 | 2 | 1 | 0.24 |
| Presence of cancer | 2 | 2 | 2 | 2 | 0.62 |
| Tobacco use | 4 | 4 | 3 | 3 | 0.78 |
| Dialysis vintage | |||||
| 0–6 mo | 15 | 10 | 9 | 9 | <0.001 |
| 6–24 mo | 34 | 28 | 22 | 21 | <0.001 |
| 2–5 yr | 36 | 39 | 39 | 33 | <0.001 |
| >5 yr | 15 | 23 | 30 | 37 | <0.001 |
| Kt/V | 1.57±0.36 | 1.61±0.36 | 1.61±0.34 | 1.63±0.37 | <0.001 |
| nPCR (g/kg per day) | 1.04±0.25 | 1.04±0.26 | 1.03±0.26 | 1.03±0.28 | 0.02 |
| Serum creatinine (mg/dl) | 10.9±3.5 | 10.6±3.4 | 10.3±3.3 | 10.1±3.3 | <0.001 |
| Serum albumin (mg/dl) | 4.02±0.38 | 3.99±0.39 | 3.94±0.41 | 3.87±0.48 | <0.001 |
| Serum phosphate (mg/dl) | 6.0±1.5 | 5.9±1.5 | 5.9±1.5 | 5.8±1.6 | <0.001 |
| Serum calcium (mg/dl) | 9.4±0.6 | 9.4±0.6 | 9.4±0.6 | 9.3±0.7 | <0.001 |
| Serum iPTH (pg/ml) | 305±224 | 386±299 | 499±402 | 727±668 | <0.001 |
| Blood hemoglobin (g/dl) | 12.2±1.3 | 12.3±1.3 | 12.2±1.3 | 12.1±1.4 | 0.003 |
| WBC (×103/L) | 6.9±2.0 | 6.9±2.1 | 7.0±2.2 | 7.1±2.4 | 0.004 |
| Number of HLA mismatch | 3.5±1.8 | 3.5±1.9 | 3.6±1.8 | 3.7±1.8 | <0.001 |
| Number of HLA-DR mismatch | 1.05±0.73 | 1.07±0.74 | 1.06±0.73 | 1.12±0.74 | 0.02 |
| PRA (%) | 8±21 | 11±25 | 11±25 | 14±28 | <0.001 |
| PRA >20% | 11 | 15 | 17 | 20 | <0.001 |
| Donor age (yr) | 39±15 | 39±15 | 39±15 | 38±16 | 0.02 |
| Donor sex (% women) | 49 | 47 | 49 | 46 | 0.08 |
| Donor type (% living) | 39 | 34 | 30 | 27 | <0.001 |
| EDC kidneya | 19 | 19 | 17 | 16 | 0.07 |
| Cold ischemia time (h)a | 18.4±8.4 | 18.5±8.5 | 18.0±8.6 | 18.3±8.6 | <0.001 |
Data are percentages or means ± SDs unless otherwise indicated. BMI, body mass index; nPCR, normalized protein catabolic rate; iPTH, intact parathyroid hormone; WBC, white blood cell count; PRA, panel reactive antibody (last value before transplant); EDC, extended donor criteria; N/A, not applicable.
a
In recipients who received kidney from deceased donors.