Table 2.
Regression coefficients for the association of urinary net acid excretion with metabolic acidosis and related cardiovascular risk factors in 707 renal transplant recipients
| Dependent Variable | SD | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|---|
| Standardized β for NAE (95% CI) | P Value | Standardized β for NAE (95% CI) | P Value | Standardized β for NAE (95% CI) | P Value | ||
| Systemic acidosis | |||||||
| Serum HCO3− in mmol/L | 3.01 | −0.08 (−0.14 to −0.02) | 0.005 | −0.17 (−0.28 to −0.05) | <0.001 | −0.16 (−0.23 to −0.10) | <0.001 |
| Cardiovascular risk factors | |||||||
| Serum pH | 0.04 | −0.10 (−0.15 to −0.03) | 0.001 | −0.20 (−0.30 to −0.07) | <0.001 | −0.18 (−0.24 to −0.12) | <0.001 |
| Systolic BP in mmHg | 17 | 0.009 (−0.51 to 0.46) | 0.97 | −0.2 (−2.13 to 2.52) | 0.87 | −0.01 (−0.05 to 0.03) | 0.75 |
| Diastolic BP in mmHg | 11 | 0.04 (−0.14 to 0.22) | 0.66 | 0.02 (−0.04 to 0.08) | 0.52 | 0.02 (−0.09 to 0.13) | 0.57 |
| Mean arterial pressure in mmHg | 12 | 0.03 (−0.21 to 2.72) | 0.80 | 0.004 (−0.01 to 0.02) | 0.64 | 0.008 (−0.29 to 0.27) | 0.84 |
| Cholesterol in mmol/L | 1.12 | −0.12 (−0.19 to −0.05) | 0.002 | −0.11 (−0.19 to −0.03) | 0.006 | −0.10 (−0.17 to −0.03) | 0.02 |
| HDL cholesterol in mmol/L | 0.48 | −0.02 (−0.06 to 0.02) | 0.28 | −0.05 (−0.13 to 0.03) | 0.20 | −0.03 (−0.06 to 0.00) | 0.46 |
| LDL cholesterol in mmol/L | 0.93 | −0.09 (−0.17 to −0.02) | 0.02 | −0.08 (−0.16 to −0.01) | 0.05 | −0.07 (−0.14 to 0.00) | 0.10 |
| Triglycerides in mmol/La | 0.47 | −0.10 (−0.19 to −0.01) | 0.03 | −0.09 (−0.20 to 0.02) | 0.12 | −0.08 (−0.19 to 0.03) | 0.06 |
| Phosphate in mmol/l | 0.21 | −0.20 (−0.29 to −0.11) | <0.001 | −0.11 (−0.16 to −0.06) | <0.001 | −0.12 (−0.21 to −0.02) | 0.003 |
| Albumin in g/L | 2.98 | 0.13 (0.03 to 0.23) | 0.01 | 0.07 (−0.01 to 0.14) | 0.06 | 0.06 (−0.06 to 0.18) | 0.13 |
| Nt-Pro-BNP in ng/La | 1.42 | −0.16 (−0.26 to −0.06) | 0.002 | −0.07 (−0.13 to −0.02) | 0.01 | −0.05 (−0.24 to 0.14) | 0.17 |
| HbA1c in %a | 0.13 | 0.05 (−0.01 to 0.12) | 0.15 | 0.03 (0.01 to 0.06) | 0.17 | 0.04 (−0.01 to 0.10) | 0.32 |
| Albuminuria in mg/24 hra | 1.92 | −0.08 (−0.26 to 0.14) | 0.39 | 0.02 (−0.13 to 0.09) | 0.72 | 0.01 (−0.01 to 0.02) | 0.75 |
| Proteinuria in g/24 hr | 1.72 | −0.07 (−0.17 to 0.03) | 0.52 | 0.04 (−0.13 to 0.05) | 0.59 | 0.02 (−0.07 to 0.11) | 0.70 |
Association of net acid excretion as independent variable, adjusted for age (years), body surface area (m2), and sex (model 1); renin-angiotensin system blockade, diuretics, calcineurin inhibitors, proliferation inhibitors, and sodium bicarbonate (yes/no) (model 2); and renal function (estimated GFR), time since renal transplantation (years), and smoking behavior (model 3). Standardized βs refer to the number of SDs the dependent variable changes per SD increase of NAE. CI, confidence intervals; HCO3−, bicarbonate; Nt-Pro-BNP, N-terminal pro-brain natriuretic peptide; HbA1c, glycosylated hemoglobin.
Log-transformed for analyses.