Figure 4 .

Bindarit’s effects on CCL2 mRNA and protein in brain and spinal cord following LPS. Mice received i.p. injection of 200 mg/kg bindarit (or vehicle) once a day for 4 days, followed by i.p. injection of 5 mg/kg lipopolysaccharide (LPS) at 30 minutes after the last bindarit treatment. At 4 hr after LPS injection, brain and spinal cord were prepared for CCL2 mRNA (A) and protein (B) determinations. LPS + bindarit-treated brain or spinal cord samples were compared to corresponding samples treated with LPS + vehicle (control). *P < 0.05; ^#P < 0.01.