Table 4.
Distribution of CDK4 mutations with area of cancer and smoking status
| Region in gene | Mutations/change in amino acid |
Area of cancer |
Smoking status |
|||
|---|---|---|---|---|---|---|
| Oral cavity (N = 224) | Pharynx (N = 97) | Larynx (N = 59) | Non smoker (N = 238) | Smokers (N = 142) | ||
| Exon 2 |
g5051G > C |
24 |
19 |
06 |
19 |
30 |
| Exon 2 |
g5095G > C |
22 |
15 |
08 |
22 |
23 |
| Intron 3 |
g5427delA |
18 |
11 |
02 |
17 |
14 |
| Exon 5 |
g5906C > A, g5907C > G |
15 |
08 |
04 |
15 |
12 |
| Exon 7 |
g7320 A > C, g7321_23delTGA |
20 |
03 |
01 |
13 |
11 |
| 3′ UTR |
g7121_7122insG |
27 |
12 |
07 |
22 |
24 |
| 3′ UTR |
g7143delG |
23 |
05 |
02 |
12 |
18 |
| Total |
|
149 |
73 |
30 |
120 |
132 |
| |
p = 0.13 |
p = 0.03 |
||||
| OR 84.0, 95% CI (65.69 to 233.69) | OR 1.84, 95% CI (1.33 -2.54) | |||||
N = number of cases.
Odd ratio (OR).
95% confidence interval (CI).