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. Author manuscript; available in PMC: 2012 Nov 5.
Published in final edited form as: Neuron. 2008 Aug 28;59(4):568–580. doi: 10.1016/j.neuron.2008.07.033

Figure 1. Expression of FAD-linked PS1 variants impairs enrichment-induced proliferation of hippocampal neural progenitors.

Figure 1

(A - F) Photomicrographs of BrdU (green or yellow)+ cells in the DG of PS1hWT (A, D), PS1ΔE9 (B, E) and PS1M146L (C, F). SH, standard housing conditions (A, B, C); EE, enriched conditions (D, E, F). NeuN, red. Scale bar: 100 μm.

(G) Quantification of BrdU+ cells (mean ± SEM; N = 10 - 15 per group). * P < 0.05.

(H) Quantification of granule cell number. * P < 0.05.

(I) Photomicrograph of primary neurospheres. Scale bar: 50 μm.

(J) Image of nestin (green)+ neurosphere. Scale bar: 25 μm.

(K) Nuclei were stained with DAPI (blue).

(L) Percentage of multipotent neurospheres obtained in clonogenic neurosphere assay (mean ± SEM, N = 5 animals per group). ** P < 0.01.