Table 1.

Cases of Endophthalmitis after Single Use Vial Intravitreal Injections in the Diabetic Retinopathy Clinical Research Network

Case	Intravitreal Drug Injected	Culture Results	Povidone-Iodine Use	Pre-op Antibiotics	Post-op Antibiotics
1	Bevacizumab	Coagulase negative staphylococcus	Yes	No	No
2	Ranibizumab	Coagulase negative staphylococcus	Yes	Yes	Yes
3	Ranibizumab	Culture negative	Yes	No	Yes
4	Ranibizumab	Coagulase negative staphylococcus	No*	Yes	Yes
5	Ranibizumab	Streptococcus viridans†	Yes	No	Yes
6	Ranibizumab	Coagulase negative staphylococcus	Yes	No	Yes
7	Masked drug (either saline or ranibizumab)	Culture negative	Yes	No	Yes

^*Among 8027 intravitreal injections in the Diabetic Retinopathy Clinical Research Network, this is the only study participant in which injections were performed without use of povidone-iodine, which was considered a protocol deviation. Since this event, the DRCR.net has clarified to participating investigators that no study injections may be performed without use of povidone-iodine over the injection site, even as a protocol deviation.

^† Scant growth of methicillin resistant staphylococcus aureus also was reported.