Table 3.
Baseline Fluorescein Leakage Area within the Grid (N=422 eyes)
| Fluorescein Leakage within Grida | |||
|---|---|---|---|
| 0 – <3 DA | ≥ 3 DA | r | |
| Baseline Visual Acuity letter score (Snellen Equivalent)b | 0.33 | ||
| ≥ 84 (≥20/20) | 92 (43%) | 36 (19%) | |
| 83–69 (<20/20 to 20/40) | 96 (45%) | 98 (53%) | |
| 68–19 (<20/40 to 20/400) | 24 (11%) | 51 (28%) | |
| Total | 212(100%) | 185 (100%) | |
| Baseline Central Subfield Thickness | 0.38 | ||
| < 300 | 154 (69%) | 101 (51%) | |
| 300 – < 425 | 54 (24%) | 50 (25%) | |
| ≥ 425 | 14 (6%) | 48 (24%) | |
| Total | 222 (100%) | 199 (100%) | |
| Baseline OCT Volumec | 0.58 | ||
| < 7 | 45 (24%) | 2 (1%) | |
| 7 – < 8 | 94 (50%) | 40 (25%) | |
| 8 – < 9 | 34 (18%) | 55 (35%) | |
| ≥ 9 | 16 (8%) | 60 (38%) | |
| Total | 189 (100%) | 157 (100%) | |
| Baseline DME area | 0.56 | ||
| < 4 DA | 180 (81%) | 82 (41%) | |
| ≥ 4 DA | 42 (19%) | 117 (59%) | |
| Total | 222 (100%) | 199 (100%) | |
| Baseline Retinal thickening at center of macula | 0.37 | ||
| None | 115 (52%) | 47 (24%) | |
| Questionable | 22 (10%) | 19 (10%) | |
| Definite, < 1X reference | 23 (10%) | 25 (13%) | |
| Definite, < 2X reference | 60 (27%) | 97 (49%) | |
| Definite, ≥ 2X reference | 2 (<1%) | 11 (6%) | |
| Total | 222 (100%) | 199 (100%) | |
| Baseline DME Severity Scale | 0.45 | ||
| Level 1 | 111 (50%) | 43(22%) | |
| Level 2 | 21 (9%) | 16 (8%) | |
| Level 3 | 29 (13%) | 27 (14%) | |
| Level 4 | 29 (13%) | 25 (13%) | |
| Level 5a | 21 (9%) | 26 (13%) | |
| Level 5b | 9 (4%) | 53 (27%) | |
| Level 5c | 2 (<1%) | 9 (5%) | |
| Total | 222 (100%) | 199 (100)% | |
a
Missing for 1 eye
b
Excluded 24 eyes with ocular abnormalities other than DME that were considered a likely cause of decreased visual acuity.
c
Missing for 75 eyes.
OCT=Optical Coherence Tomography, DME=Diabetic Macular Edema, DA=Disc Area