Table 6.
Change in Fluorescein Leakage Area (Square Root Transformation) Within Grid (N=244 eyes)
| Change in Fluorescein Leakage | |||||
|---|---|---|---|---|---|
| N | > 0.3 DD better* | Within Grid within ± 0.3 DD | > 0.3 DD worse | r | |
| Change in Visual Acuitya | 0.22 | ||||
| ≥10 letters better | 19 (9%) | 6 (3%) | 1 (<1%) | ||
| within ± 9 letters | 83 (39%) | 65 (30%) | 14 (7%) | ||
| ≥10 letters worse | 10 (5%) | 9 (4%) | 8 (4%) | ||
| Total | 215 | ||||
| Change in Central Subfield Thickness | 0.30 | ||||
| > 40 microns better | 66 (27%) | 31 (13%) | 12 (5%) | ||
| within ± 40 microns | 47 (19%) | 46 (19%) | 4 (2%) | ||
| > 40 microns worse | 13 (5%) | 15 (6%) | 10 (4%) | ||
| Total | 244 | ||||
| Change in OCT Volumeb | 0.44 | ||||
| >0.5 better** | 57 (33%) | 22 (13%) | 3 (2%) | ||
| within ±0.5 | 32 (18%) | 40 (23%) | 5 (3%) | ||
| >0.5 worse | 3 (2%) | 5 (3%) | 7 (4%) | ||
| Total | 174 | ||||
| Change in DME Area | 0.39 | ||||
| >0.3 DD better | 68 (28%) | 33 (14%) | 6 (2%) | ||
| within ±0.3 DD | 31 (13%) | 27 (11%) | 4 (2%) | ||
| >0.3 DD worse | 27 (11%) | 32 (13%) | 16 (7%) | ||
| Total | 244 | ||||
| Change in DME Severity Scale | 0.30 | ||||
| ≥2 levels better | 47 (19%) | 23 (9%) | 2 (<1%) | ||
| within ± 1 level | 59 (24%) | 50 (20%) | 16 (7%) | ||
| ≥2 levels worse | 20 (8%) | 19 (8%) | 8 (3%) | ||
| Total | 244 | ||||
*
less leakage
**
reduction in OCT retinal volume
a
Excluded 29 eyes with ocular abnormalities other than DME that were considered a likely cause of decreased visual acuity.
b
Missing for 36 eyes at baseline, 21 eyes at 12 months, and 13 eyes at both baseline and 12 months.
OCT=Optical Coherence Tomography, DME=Diabetic Macular Edema, DD=Disc Diameter