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Agonist binding after mutation of key residues. (a) Ligand contact residues. (b) Non-contact residues. Binding of epibatidine and ACh to native α7 AChRs was measured by competition against the initial rate of 125I-labeled α-bungarotoxin binding (see Online Methods). Curves are nonlinear least-squares fits of the Hill equation to the data with fit parameters given in Supplementary Table 2.
