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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: Neuroscience. 2012 Aug 3;223:365–376. doi: 10.1016/j.neuroscience.2012.07.053

Figure 3. Relationship of DC shifts and spatial extent of SD to the secondary phase of synaptic suppression.

Figure 3

A: Relationship between the duration of the DC shift and duration of secondary suppression of fEPSP amplitude. No antagonists were present in these studies, and DC durations and fEPSP recovery times were calculated as described in Experimental Procedures. Solid line: linear regression (Pearson’s R2=0.26, p<0.05, n=15). Dashed lines: 95% confidence intervals. B: Data from the same preparations as plotted in A, showing that the duration of fEPSP recovery was also predicted by the area of tissue recruited into SD (Pearson’s R2=0.29, p<0.05, n=15). The image illustrates how the spatial extent of SD was determined, from enhanced images of IOS (ΔT/T0). The perimeter was traced (dotted white line) and the enclosed area was calculated in NIH ImageJ (see Experimental Procedures).