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Orientation of α-conotoxin ImI bound to Aplysia AChBP (PDB code 2BYP; Ref. 110). Left: principal and complementary faces are shown as ribbons, while α-conotoxin ImI is shown as space-filling. Right: key AChBP determinants of affinity, based on mutagenesis analyses of α7 AChRs (213, 215), are shown as space-filling (Tyr91, Tyr186,Tyr193, Asp195, Met114, Arg77), while key determinants of α-conotoxin ImI affinity (216) are shown as ball and stick (Asp5, Pro6, Arg7, Trp10).
