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Fast channel CMS due to mutation at the entrance to the α-ε binding site (246). Left: extracellular domains of the α- and ε-subunits are shown with the mutant residue εAsp175 in standard atom colors. Right: compares single-channel currents for wild-type and mutant AChRs (channel openings are upward deflections). [From Sine et al. (246).]
