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Fast channel CMS due to a mode-switching mutation in the intracellular domain of the ε-subunit (279). Left: a homology model of the AChR (based on PDB code 2BG9) in ribbon representation with regions in which CMS localize highlighted in white space-filling representation. Right: compares individual episodes of single-channel currents for wild-type and ε411P AChRs. [From Wang et al. (279).]
