Table 1.
Loop | Residue Span | Secondary Structure | Key Residues | Defining Ligands |
---|---|---|---|---|
A | α93-97 | β4-β5 linker | Tyr93, Ala96, Asp97 | Nicotine, ACh |
B | α148-153 | β7-β8 linker | Trp149, Tyr151, Gly153 | Nicotine, ACh, d-tubocurarine |
C | α189-200 | β9-β10 linker | Tyr190, Cys192, Cys193, Tyr198, Asp200 | Nicotine, ACh, bromo-ACh, lophotoxin |
D | ε55-59, δ57-61 | β2-strand | εTrp55, εGly57, εAsp59, δTrp57, δGlu59, δGly61 | d-Tubocurarine, metocurine, nicotine, ACh, NmmI α-toxin, Waglerin I |
E | ε109-119, δ111-121 | β5′-β6-strands | εLeu109, εTyr111, εVal116, εThr117, εLeu119, δLeu111, δTyr113, δVal118, δTyr119, δLeu121 | α-Conotoxin M1, d-tubocurarine, metocurine, α -bungarotoxin, NmmI α-toxin, Waglerin I |
F | ε161-183, δ163-187 | β8-β9 linker | εAsp173, εAsp175, δIle178, δAsp180 | α-Conotoxin M1, metocurine, NmmI α-toxin, ACh, Waglerin I |
G | ε29-45, δ31-47 | β1-strand | εLys34, δAla36 | α-Conotoxin M1, carbamylcholine |
Residue positions correspond to the human endplate AChR.