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A. I –V plot of CFTR - βAR expressing oocyte demonstrating no activation by 1 µm lubiprostone with subsequent activation by isoproterenol and IBMX. B. I – V plot of CFTR - EP4 expressing oocyte activated by lubiprostone and then inhibited by CFTRinh- 172. C. Plot of conductance versus concentration of lubiprostone used to determine EC50 of lubiprostone activation of CFTR – EP4 oocyctes.
